The Higher Doses Metronidazole (MTZ) Can Prevent The Malignant Alteration Of Epithelial Displasias Cervicis Uteri
A sketchy  personal case with epithelial polypous displasia of colon sigmoideus.


In the period from 1974 -1994, I was engaged in a mass early cervical cancer detection screening. During that period, I had about 15,000 patients aged between 23 and 65, with intracervical trichomoniasis, with round, endoflagellar pseudocystic forms of parasites. In support of a close relation between chronic Trichomoniasis and cervical pathology speak my long lasting clinical observations that dysplasia areas were mostly located at Portio Vaginalis cervicis in the sector 6 and 3 clockwise, depending on the side the patient most commonly sleeps.    

In practice, such infections often have unclear PAP smear tests, commonly marked as grade 3. During the routine and careless presenting of the test results, patients usually had stressful reactions and consequent depression with consecutive dysfunction of ovaries, because of unavoidable treatment with antidepressants.

In order to avoid such situations, upon consultations with the Head of Department, I decided first to apply per oral therapy with Metronidazole (MTZ), before taking the Pap smear test. As pseudocystic forms, most commonly found in the cervical canal, are wrapped in a pathologically altered hyper viscose mucus, resistant to the mentioned therapy.  I regularly ordered 3, or even 4 doses of 2 gram MTZ, plus a single dose for the partner. Doses were applied at a 48 and after that at 72 hours rate, depending on the drug tolerance, and the fourth dose at the end of the next menstrual period, in case the first three doses failed to clean parasites from the cervical canal. I personally did microscopic tests within 2 – 3 minutes upon vital dying with Cresyl violet. In case of the stomach distress reactions, MTZ was prescribed to be taken rectally in the same doses, since the absorption by the rectal mucous membrane is slightly lower (98%) than when taken orally. Pap smear tests upon eradication of trychomonads were mostly at grade 2. Normalization of the vaginal smear test, with rare exceptions, occurred even without a local antibacterial therapy.       
Upon outbreak of the war in Bosnia and in besieged Sarajevo, beginning 1992, number of patients dropped by 95%, I stopped the project, hoping to continue it upon the war was ceased. That hadn’t happened, since the medical authorities did not reengaged me although it was  about 10 years of practice. Only much later .I learned the reason for this was that the new war time head of the department disagreed with my project, more precisely, with the unrestricted doze MTZ.

As during the 20 year period mentioned, at the stated number of approx. 15,000 women tested, I had not a SINGLE new case of  dysplasia or malignant alteration at patients with already diagnosed dysplasia. During all these 20 years I was convinced about a very close relation between the chronic trychomonas cervicitis and cervical dysplasia, differently from most of the other researchers and practitioners, as well as the voluminous  literature.      

Such conviction of mine significantly increased, after I myself have gotten ill from colon sigmoid with polypous dysplasia, possibly connected whith episode of acute prostatitis, in early youth, vith mucoid secretion and urethral stricture.Besides several gigh risk   factors in  personal case,in war conditions ortopedic pelvic dysfunktion with chronic obstipation.

Pathohistological test upon the sigmoidectomy showed polipous  dysplasia.During the post-operative care, beside lesser doses of MTZ (2 times 250 mg), I used one liter of natural juices per day, made of red beet, carrot, and fruits, in the period of two years, abstaining from chemotherapy at my own risk. Quarterly control of tumor markers in the 2 year period, showed normal values and 30 months after the surgery, colonoscopy was normal at the remaining colon. The reason for uncommonly increased doses of MTZ is the fact that the large number of mucosal glands at the ending part of the intestines enables various parasites, particularly protozoa. In case the host is already sensitized and his/her reaction did not result with a complete expulsion. Parasites were unavailable to MTZ and supported continuation of the antiparasitic immunity and its further erosion.

The concurrent long-lasting monofocal cervical and occasional remote extraurogenital Trichomonas infections could in vivo disorient and “confuse” the neuroimmune center, which coordinates distinctive branches of defense against cancer, causing a chromosomes’ chaos and mitotic arrest in prophase according records from Farris and Honigberg’s work from 1970.!!